α1-Adrenoceptor-mediated phosphorylation of myosin in rat tail arterial smooth muscle
نویسندگان
چکیده
منابع مشابه
alpha1-Adrenoceptor-mediated phosphorylation of myosin in rat-tail arterial smooth muscle.
The mechanism of alpha1-adrenoceptor-mediated contraction was investigated in helical strips of the rat-tail artery. Muscle strips with the endothelium removed contracted in response to the alpha1-adrenoceptor agonist cirazoline, with half-maximal contraction at 0.23 microM. The contractile response to a submaximal concentration of cirazoline (0.3 microM) was biphasic, with a rapid phasic compo...
متن کاملThe involvement of protein kinase C in myosin phosphorylation and force development in rat tail arterial smooth muscle.
Myosin light-chain phosphorylation is the primary mechanism for activating smooth-muscle contraction and occurs principally at Ser-19 of the 20 kDa light chains of myosin (LC(20)). In some circumstances, Thr-18 phosphorylation may also occur. Protein kinase C (PKC) can regulate LC(20) phosphorylation indirectly via signalling pathways leading to inhibition of myosin light-chain phosphatase. The...
متن کاملMyosin Phosphorylation and Crossbridge Regulation in Arterial Smooth Muscle
Regulation of rascuiar resistance is generally explained in terms of neural, hormonal, metabolic, and myogenic factors altering intracellular calcium [Ca] in vascular smooth muscle. Ca acts as a second messenger regulating the number of active crossbridges and force generation by binding to a myofilament regulatory protein. A search for the Ca-blndlng regulatory protein in arterial smooth muscl...
متن کاملCONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY
Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings...
متن کاملcontractions due to α-adrenoceptor agonists are mediated by α1-adrenoceptors in rat carotid artery
some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. the purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artely male wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. rings of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)45632-1